TECHNIQUES D'ASSEMBLAGE DES 2-METHYL-4- ARYL-1,2,3,4-TETRAHYDROISOQUINOLEINES. APPLICATION A LA SYNTHESE DES ALCALOĂŹDES CHERYLLINE ET LATIFINE
LEBRUN STÉPHANE, COUTURE AXEL, GRANDCLAUDON PIERRE* LABORATOIRE DE CHIMIE ORGANIQUE PHYSIQUE, UMR 8009 "CHIMIE ORGANIQUE ET MACROMOLÉCULAIRE", ASSOCIÉE À L'ENSCL BÂTIMENT C3(2), UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE 1, F-59655 VILLENEUVE D'ASCQ CÉDEX, FRANCE *PIERRE.GRANDCLAU
The purpose of this review is to compile the synthetic approaches to 2-methyl-4-aryl-1,2,3,4-tetrahydroisoquinolines focusing on the published literature from 1970 to present. The review is organized by bond formation and emphasis is particularly placed on the total synthesis, in racemic or enantiomerically pure forms, of the naturally occurring alkaloids cherylline and latifine.
