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APPROCHES SYNTHETIQUES ALTERNATIVES ET COMPLEMENTAIRES VERS LES ARISTOLACTAMES


RYBALKO-ROSEN HÉLÉNE, COUTURE AXEL, GRANDCLAUDON PIERRE*
UMR 8009 "CHIMIE ORGANIQUE ET MACROMOLÏ¿½CULAIRE", ASSOCIÏ¿½E Ï¿½ L`ENSCL, LABORATOIRE DE CHIMIE ORGANIQUE PHYSIQUE, BÏ¿½TIMENT C3(2), UNIVERSITÏ¿½ DES SCIENCES ET TECHNOLOGIES DE LILLE 1, F-59655 VILLENEUVE D`ASCQ CÏ¿½DEX, FRANCE, *PIERRE.GRAND

Issue:

SCSCC6, Volume VI, No. 1

Section:

Volume VI - No. 1 (2005)

Abstract:

Two conceptually new synthetic approaches to alkaloids aristolactam has been developed. They differ from the synthetic tactics employed for the construction of common precursors i.e. haloarylmethylene isoindolinones. These highly conjugated systems have been obtained by Horner reaction or E1cb elimination involving phosphorylated or dephosphorylated isoindolinones respectively. Free radical cyclization completes the synthesis of the target fused aristolactams.

Keywords:

alkaloids, aristolactams, radical cyclization, Horner reaction, aryne, enamides.

Code [ID]:

CSCC6200506V01S01A0001 [0001038]

Full paper:

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