Quick search
Go!

KINETICS OF RELEASE OF CHLORAMPHENICOL INTERCALATED IN HYDROTALCITE


FRUNZĂ MIHAELA*, POPA MARCEL, CARJA GABRIELA
TECHNICAL UNIVERSITY “GH. ASACHI” IAŞI B-DUL D. MANGERON, NO. 71A, IAŞI 700050, ROMANIA *CORRESPONDING AUTHOR: E-MAIL: MFRUNZA@CH.TUIAŞI.RO

Issue:

SCSCC6, Volume VI, No. 2

Section:

Volume VI - No. 2 (2005)

Abstract:

This paper reports the kinetic study of the release of chloramphenicol (CFN) intercalated in hydrotalcite. The release of CFN anion from the lamella of an organic-inorganic nanohybrid material, MgAl LDH_CFN nanocomposite, was found to be pH dependent. The release of CFN from the lamella of hydrotalcites at pH 2.0 was controlled by firstorder kinetics. Microbiological tests with Staphylococcus Epidermidis demonstrated an antimicrobial activity for a period of 48 h.

Keywords:

hydrotalcite, layered double hydroxides (LDH), chloramphenicol hemisuccinate, controlled release, antimicrobial activity.

Code [ID]:

CSCC6200506V02S01A0005 [0001049]

Full paper:

Download pdf


Copyright (c) 1995-2007 University of Bacu