COMPORTEMENT ELECTROCHIMIQUE ET ANTIBACTERIENNE DES DERIVES DE (1S, 2S)-2- AMINO-1-(4-NITROPHENYLE)- PROPANE-1,3-DIOL
CRISTEA CECILIA 1*, VOICULESCU G. 2, JITARU MARIA 2, MOINET C. 3 (1)UNIVERSITÉ DE MÉDECINE ET PHARMACIE « IULIU HATIEGANU », FACULTÉ DE PHARMACIE, DÉPARTEMENT DE CHIMIE ANALYTIQUE, 4 RUE PASTEUR,400 349 CLUJ-NAPOCA, ROUMANIE (2)UNIVERSITÉ BABES-BOLYAI CLUJ-NAPOCA, LABORATOIRE ASSOCIÉ FRANCOPHONE, 11 RUE ARANY JANOS, 40
Derivatives of (1S, 2S)-2-amino-1-(4-nitrophenyl)- propane-1,3-diol were studied because of their potential biological activity. Using the electrogenerated intermediates (hydroxylamine and nitroso derivatives) N-sulphonylphenylhydroxylamines and benzoxazine diones were obtained with good yields. Their antibacterial activity was investigated on several gram-negative and gram-positive bacilli by two techniques: broth-dilution method and agar-dilution method.
