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SYNTHESE ET PROFIL PHARMACOLOGIQUE DE NOUVEAUX LIGANDS NICOTINIQUES


CHARTON YVES 1, GUILLONNEAU CLAUDE 1, LOCKHART BRIAN 2, LESTAGE PIERRE 2, GOLDSTEIN SOLO 1
(1)INSTITUT DE RECHERCHES SERVIER, DIVISION DE CHIMIE A, 11 RUE DES MOULINEAUX, 92150 SURESNES, FRANCE (2)INSTITUT DE RECHERCHES SERVIER, DIVISION DE PATHOLOGIE CÉRÉBRALE, 125 CHEMIN DE RONDE, 78290 CROISSY-SUR-SEINE, FRANCE

Issue:

SCSCC6, Volume VII, No. 1

Section:

Volume VII - No. 1 (2006)

Abstract:

Different studies proofed that nicotine is able to improve cognition performances, both to humans and animals [1]. In a previous study [6] we have demonstrated that S35836-1, a carbamate analogue of acetylcholine, is a specific ligand of nicotinic neural receptors of acetylcholine (nAChRs), with influence in Alzheimer and Parkinson diseases. The present paper presents new synthesis schemes of receptors with restricted conformational mobility.

Keywords:

acetylcholine, neural receptors, Alzheimer, Parkinson, muscarinik receptors, nicotinic receptors.

Code [ID]:

CSCC6200607V01S01A0027 [0001086]

Full paper:

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