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ON ENCAPSULATING AND DELIVERY OF POLYPHENOLS IN SUPERPARAMAGNETIC POLYMER NANOSPHERES


VASILE BADESCU 1 *, LAURA E. UDREA 1, OVIDIU ROTARIU 1, RODICA BADESCU 2, GABRIELA APREOTESEI 2
(1)NATIONAL INSTITUTE OF RESEARCH AND DEVELOPMENT FOR TECHNICAL PHYSICS, 47 MANGERON BLVD., IAŞI, 700050, ROMANIA (2)TECHNICAL UNIVERSITY “GH. ASACHI”, DEPARTMENT OF PHYSICS, 67 MANGERON BLVD., IAŞI, 700050, ROMANIA *CORRESPONDING AUTHOR: BAV08@PHYS-IAŞI.

Issue:

SCSCC6, Volume IX, No. 2

Section:

Volume IX, No. 2 (2008)

Abstract:

In this work we report on an encapsulating and delivery study of a red grape skins antioxidant extract (polyphenols) in a superparamagnetic composite matrix. The encapsulating matrixes used were sodium alginate base aqueous ferrofluid, obtained by an in situ precipitation of magnetite, and chitosan in acetic acid. Red grape skins lyophilized extracts were encapsulated with two different systems: calcium alginate and calcium alginate–chitosan. FT-IR spectra were useful to confirm the interaction of the two polysaccharides. DLS measurements allowed determining the average size and size distribution of the polymeric nanoparticles encapsulating polyphenols. Transmission electron microscopy (TEM) of nanoparticles allowed studying their morphology and polydispersity. Release of the antioxidants in water was measured to analyze the diffusion and kinetic behavior of the system. Different matrix destabilizing agents (HCl 0.1 N, NaOH 0.1 N and sodium citrate 1 and 10% w/v as a calcium chelator at ambient temperature, and distilled water at 50 and 100 °C) were tested. Sodium citrate was found to be the most effective agent to disintegrate the beads. Superparamagnetic polymer nanoparticles encapsulating polyphenols opens up avenues for targeted therapy of some human diseases that are in part a result of free radical damage.

Keywords:

encapsulating, polyphenols, superparamagnetic nanocomposite, release kinetics.

Code [ID]:

CSCC6200809V02S01A0009 [0002074]

Full paper:

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