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COMPACT CONDENSED SYSTEMS THIAZOLO – PYRIDINE WITH BIOLOGICAL ACTIVITY REVIEW SYSTÈMES COMPACTS CONDENSÉES THIAZOLE – PYRIDINIQUES AVEC ACTIVITÉ BIOLOGIQUE MISE AU POINT


CRISTIANA RADULESCU*, IONICA IONITA, ELENA IRINA MOATER, CLAUDIA STIHI
UNIVERSITÉ « VALAHIA » TÂRGOVISTE, FACULTÉ DES SCIENCES ET ARTS, DÉPARTEMENT DE CHIMIE, RUE UNIRII 18-24, TÂRGOVISTE, ROUMANIE *CORRESPONDING AUTHOR: RADULESCUCRISTIANA@YAHOO.COM

Issue:

SCSCC6, Volume IX, No. 2

Section:

Volume IX, No. 2 (2008)

Abstract:

In this article are studied some thiazolo-pyridine systems, witch are obtained very easy, but witch present a great stability and a special biologic activity. In medical research the new classes of thiazolo-pyridines and thiazolo-pyridazines are known. These compounds are studied as medicaments with anti-inflammatory and analgesic action. Also, the thiazolo-pyridine products are demonstrated the special antihelminthic properties. In this paper are presented the most recent studies concerning the synthesis, characterization and evaluation of biological and therapeutically activities of the new thiazolo-pyridine systems. The originality of this study consists in the association of more active biological fragments in a single molecule: pyridinic ring or pyridine derivatives, thiazolic ring and other amino-thiazolic, thiadiazolic, and thiazinic, triazinic rings. The chemical structures of these new heterocyclic systems, obtained by chemical syntheses, will be purified by TLC and HPLC methods and characterized by spectroscopic analyses: MS, FTIR, UV-VIS, and RMN. Also, will be concerned the influence of substitutes grafted on aromatic and hetero-aromatic rings for antimicrobial activity.

Keywords:

compact condensed system, thiazolo-pyridine, thiazolic ring, biological activity, spectral analysis.

Code [ID]:

CSCC6200809V02S01A0012 [0002078]

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