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SYNTHESIS, CRYSTAL STRUCTURE AND ANTITUMOR ACTIVITY OF A Zn(II) COMPLEX WITH 1,2-PHENYLENEDIOXYDIACETIC ACID


XI-SHI TAI 1*, JIE YIN 2, YUAN-YUAN LIU 1
1. Weifang University, College of Chemistry and Chemical Engineering, Weifang 261061, P. R. China
2. College of Applied Chemistry and Environmental Engineering, Xinyang Vocational and Technical College, Xinyang 464000, P. R. China
*Corresponding author: taixishi@lzu.edu.cn

Issue:

SCSCC6, Volume XV, No. 4

Section:

Volume XV, No. 4 (2014)

Abstract:

A novel Zn(II) complex, [Zn(L)(H2O)3]·2H2O, has been obtained by reaction of Zn(OAc)2·2H2O with 1,2-phenylenedioxydiacetic acid in CH3OH/H2O. It was characterized by elemental analysis, IR and X-ray single crystal diffraction analysis. The crystal of the title complex belongs to monoclinic, space group C2/c with a = 29.283(7) Å, b = 6.7305(15) Å, c = 17.243(3) Å, β = 109.25(3)º, V = 3208.4(12) Å3, Z = 8, Dc = 1.621 mg·m-3, μ = 1.590 mm-1, F(000) = 1576, and final R1 = 0.1284, ωR2 = 0.3895. X-ray analysis reveals that the Zn(II) center is seven-coordination with a O7 distorted pengonal bipyramidal coordination environment. The Zn(II) complex molecules form 1D chain structure by the hydrogen bonds and π-π stacking interactions. The antitumor activity of 1,2-phenylenedioxydiacetic acid ligand and its Zn(II) complex against human intestinal adenocarcinoma HCT-8 cells, lung adenocarcinoma HCT-116 cells and human lung adenocarcinoma A549 cells line have been investigated.

Keywords:

antitumor activity, crystal structure, 1, 2-phenylenedioxydiacetic acid, synthesis, Zn(II) complex.

Code [ID]:

CSCC6201404V04S01A0002 [0004171]

Full paper:

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