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SYNTHESIS AND CATECHOLASE ACTIVITY OF Cu(II) AND Fe(III) COMPLEXES OF 4-METHYL-2-((PIPERIDIN-1-YL)METHYL)PHENOL


AYOWOLE O. AYENI 1, 2*, GARETH M. WATKINS 1
1. Rhodes University, Department of Chemistry, Grahamstown 6139, South Africa
2. Obafemi Awolowo University, Department of Chemistry, Ile-Ife 220005, Nigeria
*Corresponding author: aayeni@oauife.edu.ng

Issue:

SCSCC6, Volume XXI, No. 4

Section:

Volume 21, No. 4 (2020)

Abstract:

This study is aimed at evaluating the impact of

N- and S- bonding modes of thiocyanate substituent on catecholase activity as its presence in the coordination sphere of the metal complex can either reduce catecholase activity or otherwise. 4-Methyl-2-((piperidin-1-yl)methyl) phenol - the Mannich base and its synthesized metal complexes were characterized by various spectroscopic techniques including NMR, IR, and UV-Vis spectroscopy. Turnover rates obtained from the Cu(II) and Fe(III) complexes ranged between 6.02 - 22.72 h-1 with the thiocyanate mode in the Fe(III) complex leading to increased catecholase activity.

Keywords:

aminomethylation, monobase, oxidation, piperidine, quinone.

Code [ID]:

CSCC6202004V04S01A0001 [0005186]

Note:

Full paper:

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