GLYCATION OF BOVINE SERUM ALBUMIN INVESTIGATED
BY TERAHERTZ SPECTROSCOPY
GHEORGHE GRIGORE, RAZVAN AIRINI, DAN FLORIN MIHAILESCU Department of Anatomy, Animal Biology, Animal Fiziology, Biohysics and Neurobiology, University of Bucharest, Biology Faculty, Bucharest, Romania, e-mail: grigore.gheorghe321@gmail.com.
The process of glycation induces conformational changes that alter serum albumin function. This study aims to investigate the evolution of the glycation process by analyzing the Terahertz (THz) spectra of Bovine Serum Albumin unglycated and glicated with glucose and fructose. After analyzing the results we obtained and comparing the spectra of the three types of solutions we concluded that glycation of BSA by glucose produces more significant changes in the THz spectrum than the glycation by fructose.
