RECHERCHES DANS LE DOMAINE DES OXADIAZOLES 3,5-DISUBSTITUES
ZARAFU IRINA 1, IVAN LUCIA-VERONICA 1, BADEA IRINEL 2, BACIU ION 1 (1)UNIVERSITE DE BUCAREST, FACULTÉ DE CHIMIE, DÉPARTEMENT DE CHIMIE ORGANIQUE, SOS. PANDURI 90-92, SECTOR 5, ZARAFUIRINA@YAHOO.FR, IVAN_LUCIA@YAHOO.COM, ION_BACIU2004@YAHOO.COM (2)UNIVERSITE DE BUCAREST, FACULTÉ DE CHIMIE, DÉPARTEMENT DE CHIMIE ANALYTIQUE
Taking into account the practical importance of the 1,2,4- oxadiazoles [1], the paper deals with establishing the optimal synthesis methods of the 3,5-disubstituted derivates containing phenyl, stiryle and para-methoxystiryle radicals. The synthesis method uses as syntons the dithiazolium salts, and the case of 3,5-diphenyle, 3,5-distiryle and 3,5-di(pmetoxystiryle) perchlorates was studied. The compounds purity has been investigated by thin layer chromatography, and the obtained compounds have been analyzed through usual physical and chemical procedures. The antibacterial activity has been studied, concluding that 3,5-distiryle-1,2,4-oxadiazole has a remarkable antimicrobial activity.
