CHARACTERIZATION OF RUTIN-CYCLODEXTRIN INCLUSION COMPOUNDS
ANDREIA CORCIOVA 1, DAN CASCAVAL 2* 1. "Gr.T. Popa" University of Medicine and Pharmacy of Iasi, Faculty of Pharmacy, Department of Drugs Analysis, Universitatii 16, 700115 Iasi, Romania
2. "Gh. Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Department of Biochemical Engineering, D. Mangeron 73, 700050 Iasi, Romania
* Corresponding author: dancasca@ch.tuiasi.ro
The objectives of this study were to examine the potential of beta-cyclodextrin to improve the solubility of rutin and obtain inclusion compounds that were analyzed by different techniques: UV-Vis, IR spectroscopy, thermal analysis. The presence of β-cyclodextrin raises the content of rutin in water. The inclusion compounds were prepared by dry mixing, complexation in semisolid and liquid medium in 1:2 molar ratio rutin - β-cyclodextrin. The UV-Vis and IR analysis demonstrated the obtaining of inclusion compounds and the thermal analysis show that these compounds are more stable than the parent substance.
