RADU CLAUDIU FIERASCU 1, 2*, IRINA DUMITRIU 1, 2, RODICA MARIANA ION 1, 2, RALUCA IOANA BUNGHEZ 1, 2, MONICA NEAGU 3, CAROLINA CONSTANTIN 3, CRINA STAVARU 4 1. ”Valahia” University, Mechanical Engineering, Mechatronics and Robotics Department, 18-20 Unirii Blvd., 130082, Targoviste, Romania
2. National Research & Development Institute for Chemistry and Petrochemistry - ICECHIM, Analysis Department, 202 Spl. Independentei, 060021, Bucharest, Romania
3. Victor Babes National Institute for Pathology and Biomedical Sciences,
99 – 101 Spl. Independenţei, 050096, Bucharest, Romania
4. INCDMI Cantacuzino, 103 Spl. Independentei, 050096, Bucharest, Romania
*Corresponding author: radu_claudiu_fierascu@yahoo.com
Fullerenic soluble derivatives are essential for many biomedical techniques that exploit the chemical and physical properties of these unique structural carbon nanospheres. Their toxicity, demonstrated in vitro and in vivo is important for the characterization and the limitation of these applications. The photo toxicity of some fullerene molecules has been identified as a future therapeutic tool. The specific objective of the study is the synthesis of C60 derivatives. Starting from the characteristics of fullerene compounds, we tried to study in vitro C60 fullerene and some functionalized derivatives (C60 complexes with poly-vinyl pyrrolidone (PVP) and with the oxo-dimer (Fe-O)2TPP), experimental models in vitro with normal and tumor cells and investigation of their toxicological profile, in order to identify novel anti-neoplasic therapeutic devices.
