Abstract: | As known, the various maladies of the liver, alongwith the action of some toxic agents manifested at the level of this organ, determine a series of characteristic modifications in the morphophysiological parameters of the hepatic cells [5, 6, 8, 11].
A series of previous studies have been devoted to the characteristic modifications observed in alcoholic hepatopathy, expressed by immunulogical perturbations, perturbance of some enzymes’ activity [2, 6, 8, 10], modification of hepatocytes’ membrane potential and of the redox potential [6].
Another observation referred to the fact that the action of the allylic alcohol induces a series of specific modifications at the level of liver’s cells, similar to those produced in certain hepatic affections, and expressed through irreversible membranary depolarizations, modifications of the redox potential and perturbations of the ionic ratios etc. [7, 8]. Nevertheless, treatments with some acetylated polyollic products reduced such types of peturbations to a considerable extent [8].
Other investigations showed that certain polyphenolic vegetal extracts have a positive action at cellular level [4, 5, 9, 11], re-establishing the normal electrical charge of the muscular and hepatic cells membrane modified under the action of certain toxic agents [7, 8], as well as important cytostatic and antitumoral properties [10].
The present study presuming the previous investigations, follows the action of a vegetal extract of antocyanic nature on the liver of some laboratory animals intoxicated with allylic alcohol, for putting into evidence some possible hepatoprotecting effects, on considering antocyans’ polyphenolic chemical structure [1, 3]. |
