Issue:

SCSB, Volume XVII

Section:

Volume XVII - Animal Biology

Abstract:

The impact of biosynthesis and semi-synthesis agents ENLE şi D2ENLE – characterized by us in vitro as citostatici and citotoxici agents – over the carcinogen processes was investigated through successive testing in vivo of their effect over the development of limfotrop epiteliom Guérin T-8 and of carcinosarcom Walker 256. The comparative analysis of the values of evaluation indexes of antitumor activity – determined in our tests and re-tests and accomplished in the same experimental conditions with the one of reference – established by American and German preclinical screening programs, showed their compatibility. Thus, the similarity of average tumour regression of the treated samples (T) and control (C), as well as the inclusion of products T/Cx100 of re-testing between the limits of admitted variability, showed the oncochimioterapeutic effect of glycoside-furostanolici agents, natural (ENLE) and of semi-synthesis (D2ENLE), as well as their reproducibility. The qualitative evaluation of the pharmacodynamic agents ENLE and D2ENLE condition the continuation of researches, for the quantitative evaluation of their specific pharmaco-dynamic effect that will assure a pre-clinical estimation of their antitumor therapeutic efficiency.

Keywords:

[n/a]

Code [ID]:

SCSB200917V17S01A0014 [0003233]