APPROCHES SYNTHÉTIQUES VERS LES ARISTOLACTAMES – PARTIE II. CONNEXION À L`AZOTE LACTAMIQUE DE SEGMENTS HYDROCARBONÉS AMINÉS
RYBALKO-ROSEN HÉLÉNE, COUTURE AXEL, GRANDCLAUDON PIERRE* UMR 8009 "CHIMIE ORGANIQUE ET MACROMOLÉCULAIRE", ASSOCIÉE À L`ENSCL, LABORATOIRE DE CHIMIE ORGANIQUE PHYSIQUE, BÂTIMENT C3(2), UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE 1, F-59655 VILLENEUVE D`ASCQ CÉDEX, FRANCE *CORRESPONDING AUTHOR: E-M
The synthesis of a variety of polyalkoxylated aristolactams further equipped with dialkylamino chain on the lactam nitrogen atom is described. The synthetic tactics relies upon the preliminary elaboration of phosphorylated isoindolinones bearing either the requisite amino functionality or easily transformable acetal groups. Horner reaction and radical cyclization of the resulting arylmethylene isoindolinones which are also accessible by an alternative synthetic route then complete the synthesis of the target compounds.
