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UNE METHODE SIMPLE, DOUCE ET EFFICACE DE DEPROTECTION DU N-Boc PAR Na2CO3

KOUBACHI J. 1 AND 2, EL KAZZOULI S. 1 AND 2, BERTEINA-RABOIN S. 1 *, MOUADDIB A. 2, GUILLAUMET G. 1
(1)INSTITUT DE CHIMIE ORGANIQUE ET ANALYTIQUE, UNIVERSITÉ D’ORLÉANS, UMR CNRS 6005, B.P. 6759, 45067 ORLÉANS CEDEX 2, FRANCE (2)FACULTÉ DES SCIENCES ET TECHNIQUES DE BÉNI-MELLAL, UNIVERSITÉ CADI- AYYAD, BP 523, 23000 BÉNI-MELLAL, MAROC. *CORRESPONDANCE: S

Issue:

SCSCC6, Volume VII, No. 4

Section:

Volume VII, No. 4 (2006)

Abstract:

We report here, the cleavage of N-Boc by treatment using Na2CO3 with the reflux of a mixture DME/H2O. This reaction is applied to various heterocyclic structures (azaindole, indazole, pyrazole, indolinone, quinolinone, oxazolone).

Keywords:

N-Boc, Na2CO3, azaindole, indazole, pyrazole, indolinone, quinolinone, oxazolone.

Code [ID]:

CSCC6200607V04S01A0024 [0001602]

DOI:

Full paper:

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