UNE METHODE SIMPLE, DOUCE ET EFFICACE DE DEPROTECTION DU N-Boc PAR Na2CO3
KOUBACHI J. 1 AND 2 , EL KAZZOULI S. 1 AND 2 , BERTEINA-RABOIN S. 1 * , MOUADDIB A. 2 , GUILLAUMET G. 1 (1)INSTITUT DE CHIMIE ORGANIQUE ET ANALYTIQUE, UNIVERSITÉ D’ORLÉANS, UMR CNRS 6005, B.P. 6759, 45067 ORLÉANS CEDEX 2, FRANCE (2)FACULTÉ DES SCIENCES ET TECHNIQUES DE BÉNI-MELLAL, UNIVERSITÉ CADI- AYYAD, BP 523, 23000 BÉNI-MELLAL, MAROC. *CORRESPONDANCE: S
Issue:
SCSCC6, Volume VII, No. 4
Section:
Volume VII, No. 4 (2006)
Abstract:
We report here, the cleavage of N-Boc by treatment using Na2CO3 with the reflux of a mixture DME/H2O. This reaction is applied to various heterocyclic structures (azaindole, indazole, pyrazole, indolinone, quinolinone, oxazolone).
Keywords:
N-Boc , Na2CO3 , azaindole , indazole , pyrazole , indolinone , quinolinone , oxazolone .
Code [ID]:
CSCC6200607V04S01A0024 [0001602]
DOI:
Full paper:
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