SYNTHESES ET EVALUATION DES EFFETS INHIBITEURS DE L’o-PHENYLENEDIACETAMIDE ET DE CERTAINS DERIVES DE LA SERIE BENZIMIDAZOLE
LAMKADDEM A. 12*, TOUIR R. 3, ESSASSI E. M. 2, EBNTOUHAMI M. 3 1 LABORATOIRE DE SYNTHÈSE ORGANIQUE ET PROCÉDÉS D’EXTRACTION, FACULTÉ DES SCIENCES, DÉPARTEMENT DE CHIMIE, UNIVERSITÉ IBN TOFAIL KÉNITRA, MAROC 2 LABORATOIRE DE CHIMIE ORGANIQUE HÉTÉROCYCLIQUE, FACULTÉ DES SCIENCES, DÉPARTEMENT DE CHIMIE, UNIVERSITÉ MOHAM
The action of o-phenylenediamine on malonic, phenylacetic, acetic acid and on acetic anhydride was studied. Four products were insulated respectively: 2,2’-bidibenzimidazolylmethane chloride (a), 2-benzylbenzimidazolium chloride (b), 2 méthylbenzimidazolium chloride (c) and o-phenylenediacetamide (d). Their structures are supported by 1HNMR, I.R., and mass spectrometry. Their inhibiting effectiveness was given in decreasing order: a > d > b > c according to electrochemical measurements.
