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SYNTHETIC METHODOLOGIES TO THE ASSEMBLY OF CONSTITUTIONALLY DIVERSE ISOINDOLINONES. DEVELOPMENTS AND APPLICATIONS
TECHNIQUES D'ASSEMBLAGE D'ISOINDOLINONES STRUCTURELLEMENT AMENAGEES. APPLICATIONS ET DEVELOPPEMENTS


AXEL COUTURE, PIERRE GRANDCLAUDON *
UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE 1, UMR CNRS 8009 "CHIMIE ORGANIQUE ET MACROMOLÉCULAIRE", LABORATOIRE DE CHIMIE ORGANIQUE PHYSIQUE (LCOP), BÂTIMENT C3(2), F-59655 VILLENEUVE D'ASCQ CEDEX, FRANCE

Issue:

SCSCC6, Volume XI, No. 1

Section:

Volume XI, No. 1 (2010)

Abstract:

A number of conceptually new synthetic approaches to the elaboration of constitutionally diverse isoindolinones have been disclosed. The main objective was to develop synthetic tactics for the creation of the lactam unit that would allow for incorporation of appropriate functionalities liable to give access to an array of synthetic, natural and/or bioactive compounds through rather simple chemical manipulation. The flexibility and potentiality of these new processes have been further exemplified by the total synthesis of exemplary representatives in both series, i.e. alkaloids and compounds endowed with chemotherapeutic properties.

Keywords:

isoindolinones, phthalimidines, bicyclic compounds, lactams, ring closure, Parham protocol, natural products, alkaloids.

Code [ID]:

CSCC6201011V01S01A0003 [0002968]

DOI:

Full paper:

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