The main objective of this study was the investigation of the principles of food fortification with iodine. It was researched the opportunity of molecular iodine incorporation in vegetable oil, physical and chemical properties of iodized vegetable oil and other food products fortified with iodized oil. By physical and chemical methods it was established the presence of iodine-triglyceride compounds in iodized oil, formed by fixing the molecular iodine at the double bound of the unsaturated fatty acids. The results of the investigations of the physical-chemical, microbiological and organoleptic properties, the oxidation stability of iodine fortified products compared to the control samples, indicate the absence of sensitive difference during the maturation and storage processes. The iodine bioavailability in fortified lipid products has been investigated in vitro and in vivo conditions. It was established, that the recovery percent of iodine represents 57-92% (in vitro). In vivo researches have proved that iodized lipid products are influencing the metabolic processes by accumulation of iodine in animal’s body, as a result of an efficient digestion and a high iodine bioavailability from the present complexes.