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CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei


BIENVENU GLINMA 1, FERN, A. GBAGUIDI 1, SALOMÉ D. S. KPOVIESSI1, RAYMOND H. FATONDJI 1, JACQUES POUPAERT 2, GEORGES C. ACCROMBESSI1 *
1. University of Abomey-Calavi, Faculty of Sciences and Technologies, Department of Chemistry, LACOPS, 01 PB : 4521 Cotonou, Benin
2. Catholic University of Leuwen, Department of Pharmacy, CMFA, 73. 40 B-1200 Brussels, Belgium
* Corresponding author: coffiaccrombessi@yahoo.fr

Issue:

SCSCC6, Volume XII, No. 1

Section:

Volume XII, No. 1(2011)

Abstract:

The structure of four synthesized thiosemicarbazones, substituted or not, of benzophenone has been confirmed by spectrometrical analysis IR, NMR 1H and 13C. Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei. Among these compounds, benzophenone 4 phenyl-3-thiosemicarbazone 4 has the highest activity with the half-inhibitory concentration (IC50) = 8.48 micromolar (”M). Benzophenone 4-methyl-3-thiosemicarbazone 3 and benzophenone thiosemicarbazone 1 showed moderate anti-trypanosomal activity with IC50 values equal to 23.27 ”M and 67.17 ”M respectively. Benzophenone 2 methyl-3-thiosemicarbazone 2 showed no activity up to IC50 = 371.74 ”M.

Keywords:

anti-trypanosomal activities, benzophenone, half-inhibitory concentration (IC50), spectrometrical analysis, substituted thiosemicarbazones.

Code [ID]:

CSCC6201112V01S01A0007 [0003314]

Full paper:

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