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A NEW ROUTE FOR THE SYNTHESIS OF 2‑AMINOPYRIDINES
NOUVELLE VOIE DE SYNTHESE DES 2-AMINOPYRIDINES


ZAHIRA KIBOU 1, NAWEL CHEIKH 1, NOUREDDINE CHOUKCHOU-BRAHAM 1*, BACHIR MOSTEFA-KARA 1, MOHAMMED BENABDELLAH 1, DIDIER VILLEMIN 2
1. Université de Tlemcen, Faculté des Sciences, Département de Chimie, Laboratoire de Catalyse et Synthèse en Chimie Organique, B.P. 119, 13000 Tlemcen, Algérie
2. LCMT, ENSICAEN, UMR CNRS 6507, 6 Bd du Maréchal Juin, 14050 Caen, France
*Corresponding author: nbchoukchou@yahoo.fr

Issue:

SCSCC6, Volume XII, No. 2

Section:

Volume XII, No. 2(2011)

Abstract:

The 2-aminopyridines constitute a very large class of nitrogen heterocycles, which have a great biological activity, such as the antibacterial, anti-inflammatory and analgesics activity, as well as the 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinoline-3-carbonitrile has a antifungal activity. A new approach of synthesis of 2 amino-3-cyanopyridines was developed in our laboratory, based on the condensation of the intermediary of enaminonitrile with different primary amines in solvent-free environments.

Keywords:

2-amino-3-cyanopyridines, enaminonitriles, green chemistry, microwave, solvent-free.

Code [ID]:

CSCC6201112V02S01A0003 [0003339]

Full paper:

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