There are worldwide economic operators who use during the production process hazard substances which can lead to major accidents with severe consequences regarding health, the safety of persons and of the environment. This article describes a part of the measures imposed by the European legislation to prevent, prepare and for the responsibility of such technologies owners in order to identify, evaluate the risks and limit the consequences of major accidents in which are involved hazard substances. It is also a guide line for the companies which deal with goods transport (internal and international traffic) to know and to respect the most recent laws which were included in the new structure of The European Agreement referring to international transport of hazard substances and to run the activities which influence the transport security.