Rhodiola rosea L. was thoroughly studied from the pharmaceutical viewpoint, though the histo-anatomical research is scarce. In view of evincing the histo-anatomical structure of Rhodiola rosea L., cross sections were effected through roots, rhizomes, stems and leaves. The comparative research was effected both on plants originating in their native habitat (Ceahlău mountains), and on plantlets provided in vitro. The Rhodiola rosea L. plants regenerated in vitro displayed, after acclimatization and cultivation in their native environment, an anatomical structure similar to the plants from spontaneous flora, their physiological activity being normal.