This paper aims to demonstrate the utility of biochemical markers of myocardial necrosis in diagnosing and managing patients with cardiovascular disease. The studies were performed on 100 patients, between May 2018 - April 2019. Thus, in the peripheral venous blood, the following markers were determined: troponin I, pro BNP, CRP, CK, CK-MB, AST, in patients with heart disease, hospitalized in the sections of cardiology, internal medicine and ATI. All the markers used proved to be useful. Given all this wide range of tests, it remains to be established which of them have a predictive clinical value and to build a multi-marker strategy that involves different pathophysiological aspects, useful in prevention, prognosis, diagnosis and treatment.