This is a study of tolerance of some species and varieties of Cucurbitaceae to the attack of pathogens that are based on the scientific results obtained in the field. This paper aims to add studies on disease resistant species, in order to achieve these objective, other intermediate analyzes were necessary which were made using the following indicators: frequency of attack (F%), intensity of attack (I%) and the degree of attack (DA%). The results obtained from this experiment will be used in conventional and organic farming systems in order to decrease the number of diseases treatments and finding and using the most disease and pest resistant varieties of Cucurbitaceae. The trial was performed on the following cultivars: Cucurbita pepo cultivars: V1 – Aredendo T-1, V2 – Local population 2 , V3 – Milet F-1, V4 – Alburiu de Sarzana, V5 – L9 / 2018 Bacau, V6 – Gary Zucchino, V7 – Early Garden, V8 – Winter Squash, V9 – Born Free, V10 – Bush Pink Banana, V11 – Winter Squash Spaghetti, V12 – Local population 4 China, V13 – L 4 Bacau, and V14 - Local population 11. Also, on the Cucurbita moschata V15 – L 5. Luffa cylindrical V16 – L 1. From Lagenaria siceraria the following: V17 – Local population (orange pear), V18 – Local population (green pear), V19 – Local population (small pear) and V20 – Local population green with stripes. From Cucurbita maxima the V21 – Turban and from Momordica charantia V22 – Brâncuși