Lamotrigine is a broad-spectrum antiepileptic used as monotherapy or as an adjunct to other antiepileptics for the treatment of partial or generalized tonico-clonic seizures. This drug is also used in the treatment of neurological lesions, bipolar disorder, and other psychiatric disorders. The choice of the appropriate method for the routine monitoring of the drug administered to the patient with epilepsy in order to individualize the therapy, the difficulty of establishing the dose, the therapeutic field, the fluctuations of the serum concentration in certain physiological conditions (during pregnancy) imposed this study. The literature presents several methods for determining LMT and metabolites in the biological matrix including: HPLC, gas chromatography with nitrogen-phosphorus detector, mass spectrometry with thermospray chromatography, capillary electrophoresis, radioimmunoassay, immunofluorimetric analysis, UV electrophotometry, methods. In this paper, the focus was on chromatographic and spectrophotometric and electrochemical methods. Electrochemical methods with modified electrodes for LMT dosing are gaining ground lately. The choice of method aims at: simplicity of analysis, precision, accuracy, sensitivity and selectivity of the method, low analysis time, low costs.
