Abstract
Two conceptually new synthetic approaches to alkaloids aristolactam has been developed. They differ from the synthetic tactics employed for the construction of common precursors i.e. haloarylmethylene isoindolinones. These highly conjugated systems have been obtained by Horner reaction or E1cb elimination involving phosphorylated or dephosphorylated isoindolinones respectively. Free radical cyclization completes the synthesis of the target fused aristolactams.
Cuvinte cheie
alkaloids
aristolactams
radical cyclization
Horner reaction
aryne
enamides