a-(3,7-DIOXA-r-1-AZABICYCLO[3.3.0]OCT-c-5- YLMETHOXY)-DIAZINES (II): FUNCTIONALISATION VIA DIRECTED ORTHO-METALLATION AND CROSS-COUPLING REACTIONS

Abstract

The functionalisation of the title compounds via regioselective Directed ortho-Metallation (DoM), cross-coupling and the compatibility of the 3,7-DiOxa-r-1-AzaBicyclo[3.3.0]Oct-c-5-ylmethoxy system (DOABO-CH2O) to the reactions typical conditions are preliminarily reported. Its role as Directed ortho-Metallation Group (DoMG) is examined. The chelating ability of some functionalised terms as DOABO-CH2O substituting chiral diarylmethanols and polyaza analogous of 2,6-terpyridine is discussed as intramolecular steric relationships determining configuration and aptitude to bind selectively transition metals respectively.

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