NOUVELLE METHODE DE SYNTHESE ET REACTIVITE DE 2,4-DICHLORO ET DE 4-CHLORO PYRIDO[3,2-d]PYRIMIDINES
ABDELLATIF TIKAD(1)AND(2), ROUTIER SYLVAIN(1)*, AKSSIRA MOHAMED(2), LEGER JEAN-MICHEL(3), JARRY CHRISTIAN(3), GUILLAUMET GÉRALD(1)
(1)INSTITUT DE CHIMIE ORGANIQUE ET ANALYTIQUE, UNIVERSITÉ D’ORLÉANS, UMR CNRS 6005, B.P. 6759, 45067 ORLÉANS CEDEX 2, FRANCE (2)LABORATOIRE DE CHIMIE BIOORGANIQUE ET ANALYTIQUE, UNIVERSITÉ HASSAN IIMOHAMMEDIA, BP 146, 20650 MOHAMMEDIA, MOROCCO (3)EA 2962,
Abstract
New mono- and disubstituted pyrido[3,2-d]pyrimidines have been synthetized starting from 2,3-pyridinedicarboxilic anhydride. After obtaining the key intermediate 2,4-dichloropyrido[3,2-d]pyrimidine, many regioselective reactions, showed that dechlorination and SNAr have been realized in position 4. Subsequently, the residual chlorine atom in position 2 has been involved in a series of palladium-catalyzed couplings of Suzuki type.