Aminocyanopyranes 1 react respectively with diethylmalonate, acetylacetone and ethylacetoacetate to give the corresponding functional pyranopyridines 2, 3 and 4. The reaction of the compounds 2, 3 and 4 with orthoesters then with primary amines affords respectively the pyranopyridinopyrimidines 5, 7 and 8. Refluxing of the functional pyranopyridines 2 with hydrazine in ethanol leads to the pyrimidinohydrazinopyridinopyranes 6. The structures of all prepared products were determined on the basis of their IR, 1H and 13C NMR spectra.