SYNTHESE ET PROFIL PHARMACOLOGIQUE DE NOUVEAUX LIGANDS NICOTINIQUES

  • CHARTON YVES
    INSTITUT DE RECHERCHES SERVIER, DIVISION DE CHIMIE A, 11 RUE DES MOULINEAUX, 92150 SURESNES, FRANCE
  • GUILLONNEAU CLAUDE
    INSTITUT DE RECHERCHES SERVIER, DIVISION DE CHIMIE A, 11 RUE DES MOULINEAUX, 92150 SURESNES, FRANCE
  • LOCKHART BRIAN
    INSTITUT DE RECHERCHES SERVIER, DIVISION DE PATHOLOGIE CÉRÉBRALE, 125 CHEMIN DE RONDE, 78290 CROISSY-SUR-SEINE, FRANCE
  • LESTAGE PIERRE
    INSTITUT DE RECHERCHES SERVIER, DIVISION DE CHIMIE A, 11 RUE DES MOULINEAUX, 92150 SURESNES, FRANCE
  • GOLDSTEIN SOLO
    INSTITUT DE RECHERCHES SERVIER, DIVISION DE CHIMIE A, 11 RUE DES MOULINEAUX, 92150 SURESNES, FRANCE

Abstract

Different studies proofed that nicotine is able to improve cognition performances, both to humans and animals [1]. In a previous study [6] we have demonstrated that S35836-1, a carbamate analogue of acetylcholine, is a specific ligand of nicotinic neural receptors of acetylcholine (nAChRs), with influence in Alzheimer and Parkinson diseases. The present paper presents new synthesis schemes of receptors with restricted conformational mobility.

Cuvinte cheie

acetylcholine neural receptors Alzheimer Parkinson muscarinik receptors nicotinic receptors