A derivatographic investigation was performed on the thermal behavior of some polymers: chitosane, carboxymethylcellulose and systems type polymer-active principle: cloramphenicol-chitosanecarboxymethyl-cellulose. It was investigated systems in which there are covalent or ionic bold between active principle and cellulose derivates or biosyntheses polymers. The heating curves were recorded with a Paulik-Paulik-Erdei derivatograph (MOM Budapest) in static air atmospheres at heating reates 10 deg/min. Nonisothermal kinetic and thermodynamic parameters for decomposition of these systems were determined. The obtaining results revealed a multi-step degradation developing according to a complex mechanism.