INK-JET PRINTED MESOPOROUS SILICA MICRODOTS ON OPTICAL FIBER : TOWARDS ENDOSCOPIC DEVICES FOR EARLY DETECTION AND THERAPY OF CANCER

ACHRAF NOUREDDINE(1), JULIEN GRAFFION(1), ROMAIN TRIHAN(1), OLIVIA DE LOS COBOS(1), MARTINE LEJEUNE, FABRICE ROSSIGNOL(1), CLAIRE LEFORT(2), LUDOVIC MICALLEF(3), HUSSEIN AKIL(2), FABRICE LALLOUÉ(3), JÉRÔME DESROCHES(4), OLIVIER BAUDET(4), MARION PONCELET(5)

1. Ecole Nationale Supérieure de Céramique Industrielle ENSCI, Laboratoire Sciences et Procédés Céramiques et Traitement de Surface SPCTS UMR 7315. 12, Rue Atlantis 87068 Limoges, France
2. Institut de Recherche XLim-UMR CNRS 7252. 123, Avenue Albert Thomas 87060 Limoges, France
3.Université de Limoges, Faculté de Pharmacie, Laboratoire Homéostasie Cellulaire et Pathologie HCP- EA 3842. 2, Rue du Dr. Marcland 87025 Limoges, France
4. Kamax Innovative Systems. 12, Rue de Gémini 87280 Limoges, France
5. Ceradrop, 32 rue de Soyouz, Parc d’ESTER, 87068 Limoges, France

Abstract

In the present work, the objective is to develop a biosensor on the tip of optical fiber-based endoscopic device capable to detect the presence of tumors at an early stage. The innovative approach is to use the flexibility and the resolution of the inkjet printing process combined to Evaporation-Induced Self-Assembly (EISA) to achieve appropriate mesoporous silica microdots arrays functionalized by click chemistry for detection of cancers. As for this specific application, bio-receptors labeled with fluorophores are anchored to the surface of the mesoporous silica. Thus, Fluorescence Resonance Energy Transfer (FRET) is induced when bio-receptors interact with the tumor cells’ biomarker of interest. The preliminary results are obtained on glass substrates. Currently, the work is ongoing to transpose the concept on optical fibers and to be ready for non-invasive clinical tests.

Keywords

cancer diagnosis endoscopic probe optical fiber ink-jet printing functional silica microdots FRET
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