Abstract: | Correlation coefficients and associated squared values are used as assessment parameters in validation of structure-activity relationships. Seven correlation coefficients were calculated for models that characterized the relationship between chemical structure the herbicidal activity of a triazine analogues series. Three previously reported models were compared by using Pearson (rPrs), Spearman (ρSpm), Kendall's (τa, τb, τc), Gamma correlation coefficients (Γ), and a new proposed Semi-Quantitative (rsQ). The results of investigation, expressed as correlation coefficients and associated 95% confidence intervals, squared correlation coefficient, Student’s t parameters, respectively the Z parameter were calculated for each model, and the values are discussed. This approach proved to be a good tool for chemical structure versus biological activity relationships assessment. |