The studies are aimed at an evaluation of the complex diagnosis of pancreatitis, based on modern methods of investigation that include the use of specific markers that can invalidate or confirm the diagnosis (CA 19-9 and CEA) and the evaluation of lipase and amylase enzymes, in relation to the type of pancreatitis. In our study were included 70 patients admitted to the gastroenterology department, within the Bacau County Emergency Clinical Hospital, between February and May 2018. The distribution of cases according to the sex of the patients showed a slightly higher frequency of the male patients. (56%) and an equal predominance of cases in rural and urban areas regarding the forms of pancreatic pathologies. The results showed a higher number of cases in the age groups between 41 and 60 years. Plasma concentrations of amylase and lipase increase within hours of an episode of acute pancreatitis. Lipase tends to remain high longer than amylase, making it more useful when presentation to the doctor has been delayed by more than 24 hours. Both enzymes can be grown under different conditions, other than pancreatitis. None is useful in monitoring the course of the disease or in predicting the severity in adults.