Pesticides are mainly released into Lakes, ponds and rivers due to the runoff from agricultural fields. Pesticides are generally toxic to many non-target organisms such as fish. Fish, generally accumulate contaminants from aquatic environments and have been largely used in studies of food safety. The toxic effect of the chlorantraniliprole on biochemical characteristics (total protein, soluble and structural, free amino acids and lipid levels in muscle, kidney and liver) of the snake head fish Channa punctatus were estimated. The result shows declined levels of biochemical parameters during all the exposure periods when compared with control.