An experimental installation to study the laser radiation on tissues has been worked out to permit the getting of radiation impulses of various frequency and the possibility to direct the fascicle on the studied surface simultaneously with the administration of ozonized liquide. In order to determine the optimal doses of ozone in liquids, we used ozonized liquids of various concentration obtained by a photochemical method. As a result of researces we established the application doses of the laser radiation concomitantly with the aerosoles flux, containing ozonized liquids in effective treatment of marginal parodontitis.