Abstract: | In this paper two compact condensed systems with thiazolic ring, 2-aminothiazolo[4,5-f]indazole and 2-aminothiazolo[5,4-f]indazole, were synthesized. This work presents some synthesis preparative alternatives of these systems, original and unknown in literature, and for each method the reaction conditions are analyzed. Also, the structures of purified heterocyclic systems and of all intermediaries (with a support of TLC and HPLC methods) were studied, for each obtained alternative, by IR spectroscopy, UV spectroscopy, NMR, elemental analysis and melting points. Then, it was realized a comparative study between of the 2- aminothiazolo-indazoles syntheses methods about some aspects (yield, time of reaction, purity of the heterocyclic system, etc.) of reactions and the best preparative way was chosen. |