HLAB27 PROFILE IN ALGERIAN PATIENTS WITH ANKYLOSING SPONDYLITIS
NASSIMA FARAH BELDJA 1, NORIA HARIR 1*, KHALIDA ZEMRI 1, SIHEME OUALI 1, FERIEL SELLAM 2, ZOUAOUI NADJI 3, AMEL SEHIMI 4, OUASSINI BENSABER 4 1. Laboratory of Molecular Microbiology, Proteomics and Health, Department of Biology, DjillaliLiabes University of Sidibel Abbes, (EX ITMA), Algeria, North Africa, e-mail: farahnassima30@gmail.com; zemri_khalida@yahoo.ca; oualisihem16@gmail.com
2. National Center of Biotechnology (CRBt), Algeria, North Africa, e-mail: mayflowerboat@live.fr
3. Department of Internal Medicine, CHU SidiBel Abbes, Algeria, North Africa.
4. Department of Functional Rehabilitation, CHU SidiBel Abbes, Algeria, North Africa.
* Corresponding author’s
Our objective was to see if there were any differences between (HLAB27–) and (HLAB27+) individuals with ankylosing spondylitis in Western Algeria.291 patients diagnosed with (AS) at the level of rehabilitation department of (Sidi-bel-Abbes University Hospital ) were enrolled. The studied parameters were: age, gender, disease duration, age onset of disease, morning stiffness, joint and extra-articular injuries, laboratory data, disease activity, and treatments. All data were processed and analyzed via EXCEL and SPSS 22.0 (Statistical Package for the 44 Social Sciences, IBM Corporation; Chicago, IL. August 2013). Most of patients were HLAB27positive (70.79%), the mean age of disease age onset was earlier in the (HLAB27) positive group 29.46±8.99 VS 31.89±10.98 years (p= 0.001) and the morning stifness was higher in the (HLAB27) positive group 26.43 ±28.05 VS 22.00±23.36 Min. Moreover, patients with positive (HLAB27) suffer from uveitis more than patients with negative (HLAB27) 72(35.4%) VS 27(31.8%), the inflammatory parameters was higher in HLAB27 positive group and Smoking was mostly noted in this group of patients (P=0.024). Disease activity indices were significantly greater in group of positive (HLAB27) with (BASDAI) p=0.019, (ASDASCRP) p=0.007. Regarding medical treatment, Sulfasalazine and Humira were the most commonly used drugs for both groups .The presence of the (HLAB27) antigen is linked to an early start of ankylosing spondylitis in Algerian patients, as well as a high incidence of uveitis, inflammatory parameters, and disease activity indices.
