During 2020, in the Medical Analysis laboratory of the BacÄu County Emergency Hospital, a few of 123 patients infected with Treponema pallidum, of both sexes, of different ages were identified. For diagnosis, the working methods were as follows: dark field microscopy for primary syphilis in exudative lesions or tissues, VDRL flocculation reaction for the screening stage and TPHA reaction to confirm positive results. The large number of infected people shows a poor education, many number of sexual partners, so the practice of commercial sex; there are a significant number (16) cases of congenital syphilis transmitted from sick mothers. The recent high number of latent syphilis shows poor addressability to medical staff when the first symptoms of the disease appear, either due to their ignorance or shame, syphilis being a sexually transmitted disease that involves investigating the whole family, the circle of friends and of contact persons. Cases of syphilis are the prerogative of young people (second and third decade of age) and sexually active.