Abstract
The synthesis of a variety of polyalkoxylated aristolactams further equipped with dialkylamino chain on the lactam nitrogen atom is described. The synthetic tactics relies upon the preliminary elaboration of phosphorylated isoindolinones bearing either the requisite amino functionality or easily transformable acetal groups. Horner reaction and radical cyclization of the resulting arylmethylene isoindolinones which are also accessible by an alternative synthetic route then complete the synthesis of the target compounds.
Cuvinte cheie
alkaloids
aristolactams
phosphorylated amines and amides
reductive amination