Abstract
This paper reports the kinetic study of the release of chloramphenicol (CFN) intercalated in hydrotalcite. The release of CFN anion from the lamella of an organic-inorganic nanohybrid material, MgAl LDH_CFN nanocomposite, was found to be pH dependent. The release of CFN from the lamella of hydrotalcites at pH 2.0 was controlled by firstorder kinetics. Microbiological tests with Staphylococcus Epidermidis demonstrated an antimicrobial activity for a period of 48 h.
Cuvinte cheie
hydrotalcite
layered double hydroxides (LDH)
chloramphenicol hemisuccinate
controlled release
antimicrobial activity