KINETICS OF THE RELEASE OF KETOPROFEN INTERCALATED INTO LAYERED DOUBLE HYDROXIDES<br/> LA CINETIQUE DE LA LIBERATION DU KETOPROPHENE INTERCALE DANS LES HYDROXYDES DOUBLES LAMELLAIRES

Abstract

The paper presents the intercalation of ketoprofen into layered double hydroxide by the reconstruction and ion-exchange methods. The structure and composition of the intercalated material have been studied by X-ray diffraction (XRD) and FTIR spectroscopy. Drug release from the intercalation compound was performed in vitro in simulated fluid at pH 2.0 and pH 7.4. The kinetic analysis shows the importance of the diffusion through the particle in controlling the drug release rate.

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