A NEW ROUTE FOR THE SYNTHESIS OF 2‑AMINOPYRIDINES<br/> NOUVELLE VOIE DE SYNTHESE DES 2-AMINOPYRIDINES
ZAHIRA KIBOU(1), NAWEL CHEIKH(1), NOUREDDINE CHOUKCHOU-BRAHAM(1*), BACHIR MOSTEFA-KARA(1), MOHAMMED BENABDELLAH(1), DIDIER VILLEMIN(2)
1. Université de Tlemcen, Faculté des Sciences, Département de Chimie, Laboratoire de Catalyse et Synthèse en Chimie Organique, B.P. 119, 13000 Tlemcen, Algérie
2. LCMT, ENSICAEN, UMR CNRS 6507, 6 Bd du Maréchal Juin, 14050 Caen, France
*Corresponding author: nbchoukchou@yahoo.fr
Abstract
The 2-aminopyridines constitute a very large class of nitrogen heterocycles, which have a great biological activity, such as the antibacterial, anti-inflammatory and analgesics activity, as well as the 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinoline-3-carbonitrile has a antifungal activity. A new approach of synthesis of 2 amino-3-cyanopyridines was developed in our laboratory, based on the condensation of the intermediary of enaminonitrile with different primary amines in solvent-free environments.