Abstract
The 2-aminopyridines constitute a very large class of nitrogen heterocycles, which have a great biological activity, such as the antibacterial, anti-inflammatory and analgesics activity, as well as the 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinoline-3-carbonitrile has a antifungal activity. A new approach of synthesis of 2 amino-3-cyanopyridines was developed in our laboratory, based on the condensation of the intermediary of enaminonitrile with different primary amines in solvent-free environments.
Cuvinte cheie
2-amino-3-cyanopyridines
enaminonitriles
green chemistry
microwave
solvent-free