NEW SYNTHETIC APPROACH TO FUNCTIONALIZED α METHYLENE γ BUTYROLACTAMS. A NEW ACCESS TO β HYDROXYMETHYLATED MODELS OF HIGH SYNTHETIC POTENTIALITY <br/> α MÉTHYLÈNE γ BUTYROLACTAMES Á HAUT POTENTIEL SYNTHÉTIQUE. SYNTHÈSE DES DÉRIVÉS γ ALKYLÉS β HYDROXYMÉTHYLÉS

Abstract

A new technique for the elaboration of α-methylene-γ-butyrolactams hydroxymethylated at the β-position has been developed. This new synthetic approach is based upon the preliminary assembly of N protected and γ-carboxylated analogues. A subsequent reduction / elimination sequence and ultimate N-deprotection completed the synthesis of the titled compounds.

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