DEMONSTRATION OF HETEROARYLMETHANE OXIDATION IN A BENZIMIDAZOLE DERIVATIVE WITH THE USE OF UV SPECTROPHOTOMETRY AND X-RAY DIFFRACTION

KHALID ATTAR(1), YOUSSEF KANDRI RODI(2), MOHAMED BENCHIDMI(1), AMAL HAOUDI(2), FRÉDÉRIC CAPET(3), CHRISTIAN ROLANDO(4), EL MOKHTAR ESSASSI(1, 5*)

1. Laboratory of Heterocyclic Organic Chemistry, URAC 21, “Mohammed V” University, Agdal-Rabat, Morocco
2. Laboratory of Applied Organic Chemistry, Organic Chemistry Department, Faculty of Science and Techniques, “Sidi Mohammed Ben Abdellah” University, Fès, Morocco
3. Unité de Catalyse et de Chimie du Solide (UCCS), UMR 8181, Ecole Nationale Supérieure de Chimie de Lille, France
4. USR 3290, Miniaturisation pour l’Analyse, la Synthèse et la Protéomique, Université Lille 1, 59655 Villeneuve d’Ascq Cedex, France
5. Institute of Nanomaterials and Nanotechnology, MAScIR, Rabat, Morocco
* Corresponding author: emessassi@yahoo.fr

Abstract

In this work, we present the synthesis of a copper complex of 1-benzyl-2-[(5-methyl-isoxazol-3-yl)methyl]-benzimidazole, by using simultaneously UV spectrophotometry and X-ray diffraction. It has been possible for us to highlight an original oxidation of benzylbenzimidazole group in such complex leading to ketone. A kinetic study carried out by UV spectrophotometry shows well that the oxidation reaction proceeds according to the first-order kinetic law: K = 9.4×10-4 s-1 and t½ = 12.4 min.

Keywords

complexation functionalised benzimidazole kinetic UV spectrophotometry X-ray study
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