DEMONSTRATION OF HETEROARYLMETHANE OXIDATION IN A BENZIMIDAZOLE DERIVATIVE WITH THE USE OF UV SPECTROPHOTOMETRY AND X-RAY DIFFRACTION

  • KHALID ATTAR
    Laboratory of Heterocyclic Organic Chemistry, URAC 21, “Mohammed V” University, Agdal-Rabat, Morocco
  • YOUSSEF KANDRI RODI
    Laboratory of Applied Organic Chemistry, Organic Chemistry Department, Faculty of Science and Techniques, “Sidi Mohammed Ben Abdellah” University, Fès, Morocco
  • MOHAMED BENCHIDMI
    Laboratory of Heterocyclic Organic Chemistry, URAC 21, “Mohammed V” University, Agdal-Rabat, Morocco
  • AMAL HAOUDI
    Laboratory of Applied Organic Chemistry, Organic Chemistry Department, Faculty of Science and Techniques, “Sidi Mohammed Ben Abdellah” University, Fès, Morocco
  • FRÉDÉRIC CAPET
    Unité de Catalyse et de Chimie du Solide (UCCS), UMR 8181, Ecole Nationale Supérieure de Chimie de Lille, France
  • CHRISTIAN ROLANDO
    USR 3290, Miniaturisation pour l’Analyse, la Synthèse et la Protéomique, Université Lille 1, 59655 Villeneuve d’Ascq Cedex, France
  • EL MOKHTAR ESSASSI
    Laboratory of Heterocyclic Organic Chemistry, URAC 21, “Mohammed V” University, Agdal-Rabat, Morocco
    emessassi@yahoo.fr

Abstract

In this work, we present the synthesis of a copper complex of 1-benzyl-2-[(5-methyl-isoxazol-3-yl)methyl]-benzimidazole, by using simultaneously UV spectrophotometry and X-ray diffraction. It has been possible for us to highlight an original oxidation of benzylbenzimidazole group in such complex leading to ketone. A kinetic study carried out by UV spectrophotometry shows well that the oxidation reaction proceeds according to the first-order kinetic law: K = 9.4×10-4 s-1 and t<sub>½</sub> = 12.4 min.

Cuvinte cheie

complexation functionalised benzimidazole kinetic UV spectrophotometry X-ray study