SYNTHESIS AND ANTIBACTERIAL STUDY OF NOVEL BENZIMIDAZOLIUM DERIVATIVES
Hamid Ennajih(1,2), Farida Ohmani(3), Rachid Bouhfid(1), El Mokhtar Essassi(1,2*)
1 INANOTECH (Institute of Nanomaterials and Nanotechnology), MASCIR (Moroccan Advanced Science, Innovation and Research) Foundation, ENSET, Avenue de l’Armée Royale, Madinat El Irfane 10100, Rabat, Morocco 2 Université Mohammed V-Agdal, Faculté des Sciences, Laboratoire de Chimie Organique Hétérocyclique, URAC 21, Avenue Ibn Batouta BP 1014, Rabat, Morocco 3 Institut National d’Hygiène, Laboratoire de Microbiologie Médicale, Rabat, Morocco *Corresponding author: emessassi@yahoo.fr
Abstract
Condensation of o-phenylenediamine with formic acid, acetic acid and glycolic acid gave a series of benzimidazole which on reaction with alkyl halide in phase transfer catalysis afforded the formation of the corresponding 1,3-dialkylbenzimidazolium salts. The structure has been established on the basis of spectroscopic and spectrometric analysis (1H and 13C NMR, IR, MS and single X-ray diffraction). The in vitro antibacterial activities of these salts have been investigated.